Urology
July 18, 2026
5 min read

Varikosel Erkek Kısırlığına (İnfertilite) Nasıl Neden Olur?

Op. Dr. Fettah Tosun

Op. Dr. Fettah Tosun

Üroloji Uzmanı

The Relationship Between Varicocele and Male Infertility

Varicocele stands out as one of the most common and, more importantly, treatable causes of male infertility. Varicocele is the enlargement, twisting, and dysfunction of the veins that drain deoxygenated blood from the testicles, similar to varicose veins in the legs. In my clinic in Adana, especially for patients coming from the Çukurova and Mediterranean regions, varicocele is one of the first clinical conditions I evaluate in men presenting with infertility issues.

So, how does this vascular enlargement in the scrotum damage sperm cells at a microscopic level and lead to infertility? Based on my clinical experience and modern urological literature, I would like to explain these mechanisms in detail.

Mechanisms of How Varicocele Damages Sperm

  • Intra-Testicular Heat Increase (Hyperthermia): Testicles are located outside the body inside the scrotum to produce healthy sperm in an environment about 1.5 - 2 degrees Celsius cooler than core body temperature. Pooled warm blood due to varicocele disrupts this delicate temperature balance. This heat increase directly hinders sperm production (spermatogenesis), lowers sperm count, and reduces motility.
  • Oxidative Stress and DNA Damage: The pooled blood leads to an increase in free oxygen radicals (oxidative stress). This damages the sperm cell membrane and, crucially, causes sperm DNA fragmentation. Even if a sperm with DNA damage fertilizes an egg, the embryo quality remains low, which may lead to miscarriage.
  • Accumulation of Toxic Metabolites: Due to valve insufficiency in the dilated veins, metabolic waste and toxic substances from the adrenal glands reflux back into the testicles. The accumulation of these toxins damages testicular tissue, especially Leydig and Sertoli cells.
  • Lack of Oxygen (Hypoxia): The slowing down and pooling of blood prevent the testicular tissue from being nourished with fresh, oxygenated blood. This cellular hypoxia prevents the testicles from functioning healthily.
  • Which Patients Should Undergo Varicocele Treatment?

    Not every man with a varicocele suffers from infertility. The decision to treat is made by evaluating the patient's clinical condition, physical examination, and semen analysis (spermiogram) results as a whole. The basic treatment criteria I apply in my clinic are:

    • Inability of married couples to conceive despite 1 year of unprotected sexual intercourse,
    • Detection of significant deterioration in sperm count, motility, or morphology (structure) in semen analysis,
    • Presence of clinically palpable (Grade 2 or Grade 3) varicocele during physical exam,
    • In younger patients, loss of testicular volume (atrophy) or severe testicular pain that impairs quality of life.
    • The Gold Standard Treatment: Microsurgical Varicocelectomy

      The most successful method with the lowest complication rate recognized in modern medicine for varicocele treatment is Microsurgical Varicocelectomy. I perform this operation meticulously in Adana, utilizing high-resolution surgical microscopes.

      The advantage of the microsurgical approach is that it allows the preservation of very thin testicular arteries, lymphatic vessels, and the vas deferens, while identifying and ligating the diseased veins one by one. Consequently, postoperative risks like hydrocele (fluid accumulation in the scrotum) or testicular atrophy due to arterial damage are virtually non-existent.

      Frequently Asked Questions (SGE Compatible Q&A)

      How long after varicocele surgery do sperm values improve?

      The sperm production cycle takes about 74 days. Therefore, we perform the first semen analysis at the 3rd month post-surgery, and observe the definitive improvement at the 6th and 9th-month follow-ups. We see significant improvement in sperm parameters in a large majority of our patients.

      Does one-sided varicocele affect both testicles?

      Yes, varicocele occurs on the left side in 90% of cases. However, the warm blood and toxic substances pooling on the left side can adversely affect the right testicle as well, due to vascular connections between the two testicles, reducing overall sperm quality.

      Conclusion and Recommendation

      Early diagnosis and the correct surgical technique in male infertility treatment significantly increase your chances of becoming a father. If you are struggling to conceive, or if you feel pain or fullness in your testicles, you should be examined by an expert urologist without delay. I would be pleased to welcome you to my clinic in Adana for modern diagnostics and microsurgical treatment.

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